Open heavy flavor measurements with PHENIX at RHIC The production of heavy flavor, i.e. charm or beauty quarks, is an important probe of the hot and dense medium created in high energy nuclear collisions. Heavy quark-antiquark pairs are produced dominantly in initial hard parton scattering processes and form either bound quarkonia or hadronize into separate particles carrying open heavy flavor. The latter do not only provide an important baseline for quarkonia measurements but are a sensitive probe of the medium themselves. One approach to study heavy flavor in nuclear reactions is to investigate the leptonic decay channels of particles carrying heavy flavor. At RHIC, the PHENIX experiment has conducted a systematic study of open heavy flavor production in p+p, d+Au, and Au+Au collisions at 200 GeV. Selected results will be discussed.